The visitors, who sit second in La Liga, went ahead when Kylian Mbappe picked out Ferland Mendy, who squared for Brahim Diaz to slot into an empty net from close range.
Madrid had a couple of chances to double their lead before Johnny Cardoso equalised with a 34th-minute header from Isco’s corner.
Isco – captaining Betis against the club where he spent nine years – then netted a 54th-minute penalty after Antonio Rudiger had fouled Jesus Rodriguez in the box.
The hosts almost got a third when Cucho Hernandez shot wide after being picked out by Manchester United loanee Antony, who was available after his side won an appeal against his red card last week.
Betis, managed by ex-Madrid and Manchester City boss Manuel Pellegrini, move up to sixth in the La Liga table and fully deserved their victory with 18 shots to Madrid’s nine.
It was the fourth time this season Carlo Ancelotti’s side have lost in La Liga and they remain behind Barcelona on goal difference.
Atletico Madrid could overtake them with a win against Athletic Bilbao later on Saturday (20:00 GMT).
Credit: BBC
